The Correlation Between Micronutrient Intake and Nutritional Status with the Immune System During the COVID-19 Pandemic
DOI:
https://doi.org/10.55927/ijis.v4i12.774Keywords:
Nutritional Status, Micronutrient Intake, Immune SystemAbstract
Micronutrient intake consists of vitamins and minerals, which are nutrients the body requires in adequate amounts. Nutrients are crucial for supporting the optimal functioning of the immune system. The immune system is the human body's natural defense against infection by viruses and bacteria. This study employed an observational analytic design with a cross-sectional approach. This study was conducted among 89 dentistry students from UMY, specifically the 2018 class. Nutritional status was assessed using BMI data, while micronutrient intake was evaluated using the 24-hour food recall form. The immune system was assessed using the Immune System Questionnaire (ISQ). The study's results revealed that the nutritional status of 65.17% of subjects fell within the normal nutritional category, 15.73% within the overnutrition category, and 19.10% within the undernutrition category. The adequacy of vitamins B1, B2, B6, and C indicated that most subjects fell into the low category (below the Nutritional Adequacy Intake). The description of the immune system revealed that 75.28% of subjects did not experience a decrease in their immune system. In comparison, the remaining 24.72% of subjects experienced a decrease in their immune system. In the results of statistical tests using the Spearman rank correlation for nutritional status and the immune system, a sig (2-tailed) value of <0.05 was obtained. Meanwhile, the results of statistical tests on the correlation between micronutrient intake (Vitamins A, B1, B2, B6, C, Calcium, and Zinc) and the immune system yielded a significant (2-tailed) p-value of >0.05. In conclusion, a significant relationship exists between nutritional status and the immune system; however, no significant relationship is found between micronutrient intake and the immune system
References
Almatsier S. Prinsip Dasar Ilmu Gizi. 9th ed. Jakarta: PT Gramedia Pustaka Utama; 2015.
Amelia RR. Prevalensi dan zat gizi mikro dalam penanganan stunting. J Ilmu Kedokt dan Kesehat. 2019 Dec 30;6(2):138–45. Available from: http://ejurnalmalahayati.ac.id/index.php/kesehatan/article/view/2193
Angraini DI, Ayu RP. The Relationship Between Nutritional Status and Immunonutrition Intake With Immunity Status. Juke J Kedokt. 2014;4(8):158–65.
Brown MJ, Ameer MA, Daley SF, Beier K. Vitamin B6 Deficiency [Internet]. StatPearls. 2025. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30037155
Calder PC, Carr AC, Gombart AF, Eggersdorfer M. Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections. Nutrients. 2020 Apr 23;12(4):1181. Available from: https://www.mdpi.com/2072-6643/12/4/1181
Dieny FF, Maadi AK, Wijayanti HS, Tsani AFA, Nissa C. Asupan zat gizi dan kadar hemoglobin wanita prakonsepsi di Kabupaten Semarang. Indones J Hum Nutr. 2019 Dec 31;6(2):70–83. Available from: https://ijhn.ub.ac.id/index.php/ijhn/article/view/324
Dwimawati E. Gambaran status gizi berdasarkan antropometri pada mahasiswa Fakultas Ilmu Kesehatan Masyarakat Universitas Ibn Khaldun Bogor. PROMOTOR. 2020 Feb 15;3(1):50–5. Available from: https://ejournal.uika-bogor.ac.id/index.php/PROMOTOR/article/view/3144
Ernawaty E, Punuh MI, Asrifuddin A. Gambaran Kecukupan Asupan Mineral Mikro Pada Mahasiswa Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi Semester Iv Selama Masa Pandemi Covid-19. J KESMAS [Internet]. 2021;10(5):30–5.
Gupta S, Brazier AKM, Lowe NM. Zinc deficiency in low‐ and middle‐income countries: prevalence and approaches for mitigation. J Hum Nutr Diet [Internet]. 2020 Oct 6;33(5):624–43. Available from: https://onlinelibrary.wiley.com/doi/10.1111/jhn.12791
Hartoyo E, Sholihah Q, Fauzia R, Rachmah DN. Sarapan Pagi & Produktivitas. Malang: Universitas Brawijaya Press; 2015.
Lewa AF. Hubungan asupan protein, zat besi dan vitamin C dengan kejadian anemia pada remaja putri di MAN 2 Model Palu. J Publ Kesehat Masy Indones. 2017;3(1).
Mantur RP, Punuh MI, Amisi MD. Gambaran kecukupan mineral makro pada mahasiswa semester II Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi Manado selama masa pandemi COVID-19. J Kesehat Masy. 2021;10(1):86–94. Available from: https://ejournal.unsrat.ac.id/index.php/jkesmas/article/view/6544
Medawati A, Rahmawati AD, Andriani I, Aprilyanti L. Universitas Muhammadiyah Yogyakarta Dental Students’ Macronutrient Intake, Nutritional Status, and Immune System in the Context of the COVID-19 Pandemic. Int J Sci Multidiscip Res. 2025 Feb 28;3(2):357–68. Available from: https://mryformosapublisher.org/index.php/ijsmr/article/view/77
Medawati A, Utami MK, Andriani I, Rahmawati AD. Overview of Vitamin D Intake, Sun Exposure, and Immune System in College Students during the COVID-19 Pandemic Period. In: the 1st new Dental research Exhibition and Meeting (new dream) [Internet]. 2024. p. 020038. Available from: https://pubs.aip.org/aip/acp/article-lookup/doi/10.1063/5.0215995
Nasaru U, Kapantow NH, Malonda NS. Gambaran asupan vitamin larut lemak mahasiswa semester VI Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi saat pembatasan sosial masa pandemi COVID-19. J KESMAS. 2021;10(1):78–85. Available from: https://ejournal.unsrat.ac.id/index.php/jkesmas/article/view/6543
Nurmasitoh T. Physical activities, exercises, and their effects to the immune system. J Kedokt dan Kesehat Indones Internet]. 2015 Sep 20;7(2):52–8. Available from: [http://journal.uii.ac.id/index.php/JKKI/article/view/4502
Polak CL, Malonda NSH, Amisi MD. Gambaran Kecukupan Vitamin Larutan Air Pada Mahasiswa Semester VI Di Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi Manado Selama Pandemi Covid-19. J KESMAS. 2021;10(2):26–34.
Pratiwi RA. Gambaran Pola Konsumsi Vitamin C, B1, dan B6 pada Siswi Premenstrual Syndrome (PMS) di MAN 1 Semarang. Universitas Muhammadiyah Semarang; 2018.
Rawung RJH, Malonda NSH, Sanggelorang Y. Gambaran Asupan Vitamin Larut Air Mahasiswa Angkatan 2019 Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi Pada Masa Pembatasan Sosial Covid-19. Kesmas [Internet]. 2021;10(1):14–22. Available from: https://ejournal.unsrat.ac.id/index.php/kesmas/article/view/32213
Siswanto S, Budisetyawati, Ernawati F. Peran beberapa zat gizi mikro dalam sistem imunitas. Gizi Indones. 2014 Aug 30;36(1):57-64. Available from: https://persagi.org/ejournal/index.php/Gizi_Indon/article/view/116
Sudiarmanto AR, Sumarmi S. The Correlation between Calcium Intake, Zinc Intake and Stunting Prevalence on SMP Unggulan Bina Insani Surabaya Students. Media Gizi Kesmas. 2020;9(1):1–9.
Sumarmi S. Kerja Harmoni Zat Gizi dalam Meningkatkan Imunitas Tubuh Terhadap Covid-19: Mini Review. Amerta Nutr. 2020 Sep 29;4(3):250-256. Available from: https://e-journal.unair.ac.id/AMNT/article/view/19026
Thaha ILM. Peran mikronutrien di dalam perbaikan kualitas imunitas penderita multi drug resisten tuberkulosis (MDR-TB). J MKMI. 2010;6(2):113–6.
Tufan A, Avanoğlu Güler A, Matucci-Cerinic M. COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs. Turk J Med Sci. 2020 Apr 21;50(SI-1):620–32. Available from: https://journals.tubitak.gov.tr/medical/vol50/iss9/19
Unawekla J V., Moeis ES, Langi YA. Hubungan antara Status Gizi dan Sistem Imun Seluler pada Subyek Penyakit Ginjal Kronik Stadium V Hemodialisis di Instalasi Tindakan Hemodialisis RSUP Prof. Dr. R. D. Kandou Manado. E-CliniC. 2018;6(1).
Wanty W, Widyastuti N, Purbosari E. Asupan Zat Gizi Makro, Status Gizi, dan Status Imun pada Vegetarian dan Non-Vegetarian. J Nutr Coll. 2017 Jul;6(3):234.
Wijayanti N. Fisiologi Manusia dan Metabolisme Zat Gizi. Malang: Universitas Brawijaya Press; 2017.
World Health Organization. Coronavirus Disease [Internet]. 2020. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019
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